Anti-Toxoplasma gondii efficacy of beta, beta-dimethylacrylshikonin and isobutyrylshikonin in vitro and in vivo
This study demonstrated that DMAS and IBS have an inhibitory effect on T. gondii infection in vitro and in vivo, probably associated with the disruption of nucleotide metabolism in the parasite. These results highlight that the two monomers, in particular DMAS, hold promise as a potential therapeutic medicine for toxoplasmosis.
Authors
- Lu Wang (ORCID: https://orcid.org/0000-0002-4392-4882)
- Shi-Chen Xie (ORCID: https://orcid.org/0000-0003-4512-4632)
- Hai-Ting Guo
- Xingquan Zhu (ORCID: https://orcid.org/0000-0003-4129-9611)
- Bintao Zhai (ORCID: https://orcid.org/0000-0002-6378-2527)
- Zhong-Yuan Li (ORCID: https://orcid.org/0000-0001-7273-6189)
- Wen-Bin Zheng
Institutions
- Shanxi Agricultural University (CN)
- Guilin Medical University (CN)
- Guangxi Academy of Special Crops (CN)
- Lanzhou Institute of Husbandry and Pharmaceutical Sciences (CN)
Publication Details
- Journal
- Parasites & Vectors
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1186/s13071-025-06865-1
- Citations
- 1
- Primary Topic
- Toxoplasma gondii Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.05
Funders
- Shanxi Agricultural University
- Bijzonder Onderzoeksfonds UGent