Targeting USP47 enhances immunotherapy in hepatocellular carcinoma by destabilizing PD-L1
USP47 is essential for modulating proliferation, migration, invasion, and immune evasion of HCC cells. Inhibiting USP47 in combination with PD-1 blockade can enhance the suppression of HCC growth, potentially holding clinical importance. This investigation elucidates the role of USP47 in PD-L1 stability via deubiquitination, offering a new prognostic indicator and potential target for treating HCC.
Authors
- Ting Le
- Yue Wei (ORCID: https://orcid.org/0000-0002-2288-8405)
- Yixiao Jiang (ORCID: https://orcid.org/0000-0002-2104-4382)
- Jie Wang (ORCID: https://orcid.org/0000-0001-6669-8171)
- Ze Yu (ORCID: https://orcid.org/0000-0002-5849-3413)
- Guoqiang Zhang (ORCID: https://orcid.org/0000-0001-9115-3739)
- Ziqi Li (ORCID: https://orcid.org/0000-0002-1479-0619)
- Chen Yang (ORCID: https://orcid.org/0000-0003-2415-1076)
- Haijie Ma (ORCID: https://orcid.org/0000-0003-4988-2000)
- Yixin Wu (ORCID: https://orcid.org/0000-0002-4220-5536)
Institutions
- Wenzhou Medical University (CN)
- Zhoushan Hospital (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1016/j.intimp.2025.115024
- Citations
- 3
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 3.14
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Zhejiang Province