Unexpected Digit: Isolated Acrometastasis to the Fifth Finger in Advanced Lung Cancer

Acrometastasis is a rare manifestation of metastatic disease that affects the distal extremities and can occur as a complication of non-small-cell lung cancer. It is often associated with advanced disease and may coincide with other skeletal or systemic metastases. Management options typically include a combination of surgical intervention, radiation therapy, and systemic treatment. This report presents a case of an isolated acrometastatic lesion in the fifth digit of a patient with stage IV squamous cell carcinoma, without evidence of additional metastatic bone involvement. We explore diagnostic and therapeutic strategies for such presentations and emphasize the importance of a multidisciplinary approach in optimizing patient care. We also address the underlying pathophysiology and potential mechanisms contributing to acrometastatic spread.

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Publication Details

Journal
Cureus
Published
2025-06-09
DOI
https://doi.org/10.7759/cureus.85646
Primary Topic
Cancer Diagnosis and Treatment
Type
article
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article

Unexpected Digit: Isolated Acrometastasis to the Fifth Finger in Advanced Lung Cancer

Faheez Mohamed, Zakaria Alameddine, Parima Saxena, Micha Gooden et al.
Cureus
Cancer Diagnosis and Treatment
article

Unexpected Digit: Isolated Acrometastasis to the Fifth Finger in Advanced Lung Cancer

Faheez Mohamed, Zakaria Alameddine, Parima Saxena, Micha Gooden, Elvira Neculiseanu
article en

Abstract

Acrometastasis is a rare manifestation of metastatic disease that affects the distal extremities and can occur as a complication of non-small-cell lung cancer. It is often associated with advanced disease and may coincide with other skeletal or systemic metastases. Management options typically include a combination of surgical intervention, radiation therapy, and systemic treatment. This report presents a case of an isolated acrometastatic lesion in the fifth digit of a patient with stage IV squamous cell carcinoma, without evidence of additional metastatic bone involvement. We explore diagnostic and therapeutic strategies for such presentations and emphasize the importance of a multidisciplinary approach in optimizing patient care. We also address the underlying pathophysiology and potential mechanisms contributing to acrometastatic spread.

CureusVol. 17(6)
SUNY Downstate Health Sciences University (US)
Good health and well-being
Openalex Percentile: Top 80%
Cancer Diagnosis and Treatment
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Unexpected Digit: Isolated Acrometastasis to the Fifth Finger in Advanced Lung Cancer — Faheez Mohamed, Zakaria Alameddine, et al. · Cureus (2025) | TGRS Research Map | TGRS