Mechanisms of tumor heterogeneity in TACE-resistant liver cancer: Insights from single-cell and whole-exome sequencing
CTNNB1 mutations elevate ITGB1, activate PI3K/AKT, induce epithelial-mesenchymal transition, enhancing proliferation, migration, and angiogenesis, contributing to TACE resistance, suggesting novel therapeutic targets in HCC through signaling pathway interventions.
Authors
- Jihan Liu
- Wang Zhang (ORCID: https://orcid.org/0009-0008-6043-6574)
- Yue Zhang
- Zhaoyu Liu (ORCID: https://orcid.org/0000-0002-9894-9622)
- Liang Yang
- Wei Ran
Institutions
- Jinzhou Central Hospital (CN)
- Beijing Chaoyang Emergency Medical Center (CN)
- Jinzhou Medical University (CN)
- China Medical University (CN)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1097/hc9.0000000000000705
- Citations
- 1
- Primary Topic
- Cancer Mechanisms and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 1.47