Serum amyloid A1–induced intrahepatic regulatory T-cell dysfunction drives autoimmune hepatitis progression
Intrahepatic Tregs exhibit a diminished suppressive phenotype and an enhanced effector phenotype, failing to control the escalating inflammation in AIH. AIH treatment should not only focus on increasing Treg numbers but also on restoring their functional capacity.
Authors
- Hai Hui Huang (ORCID: https://orcid.org/0000-0001-7430-0119)
- Dean Tian (ORCID: https://orcid.org/0000-0002-1407-6351)
- Mei Liu (ORCID: https://orcid.org/0000-0002-7073-6174)
- Shangshu Nie
- Jianyu Yu (ORCID: https://orcid.org/0000-0002-1856-2189)
- Hao Li (ORCID: https://orcid.org/0000-0002-9886-1874)
- Han Wang (ORCID: https://orcid.org/0000-0002-1253-5972)
- Lei Yu (ORCID: https://orcid.org/0000-0002-8837-2022)
- Shuhui Wang (ORCID: https://orcid.org/0000-0002-1022-9349)
- Wei Yan (ORCID: https://orcid.org/0009-0002-4403-1098)
- Xinxia Feng
- Zheng Huang (ORCID: https://orcid.org/0000-0001-5143-5192)
- Ping Han (ORCID: https://orcid.org/0009-0002-1505-790X)
- Yujia Xia (ORCID: https://orcid.org/0000-0002-5674-3554)
- Claire Chenwen Zhong
- Yu Chen (ORCID: https://orcid.org/0000-0002-9281-193X)
Institutions
- University of Iowa (US)
- Feinstein Institute for Medical Research (US)
- Chinese University of Hong Kong (HK)
- Hong Kong Jockey Club (HK)
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- Hepatology
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1097/hep.0000000000001419
- Citations
- 2
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 2.64