Tumor microenvironment heterogeneity and progression mechanisms in intrahepatic cholangiocarcinoma: A study based on single-cell and spatial transcriptomic sequencing
The TME of ICC was heterogeneous. ASPH markedly enhanced ICC invasion The ASPH inhibitor CEP significantly inhibits ICC progression and may serve as a targeted therapeutic drug for ICC. Tumor cells in N1 lymph nodes demonstrate high expression of tumor-specific MHC-II molecules, but silencing of co-stimulatory factors such as CD80/CD86 induces CD4+ T cells into an anergic state. Our study indicated that ASPH and MHC-II may serve as novel therapeutic targets for ICC.
Authors
- Feng Shen (ORCID: https://orcid.org/0000-0002-8904-9745)
- Hui Xue (ORCID: https://orcid.org/0000-0002-2685-2821)
- Lei Xu (ORCID: https://orcid.org/0000-0002-9241-7019)
- Kui Wang (ORCID: https://orcid.org/0000-0002-4935-0533)
- Yao Li (ORCID: https://orcid.org/0009-0007-2980-5274)
- Yong Xia (ORCID: https://orcid.org/0000-0002-7678-4716)
- Lei Wang (ORCID: https://orcid.org/0009-0001-3256-2636)
- Fengwei Li (ORCID: https://orcid.org/0000-0002-1355-4809)
- Wenxin Wei
- Lishan Wang
Institutions
- Nanjing University of Chinese Medicine (CN)
- Second Military Medical University (CN)
- Shanghai Jiao Tong University (CN)
- Nanjing Drum Tower Hospital (CN)
- Shanghai First People's Hospital (CN)
- Eastern Hepatobiliary Surgery Hospital (CN)
Publication Details
- Journal
- Hepatology
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1097/hep.0000000000001423
- Citations
- 3
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 6.02