Arid1a deficiency promotes hepatocyte hyperpolyploidy and drives intrahepatic cholangiocarcinoma in mice
Hepatocytes can transform into ICC through a process involving hyperpolyploidization. This study offers new insights into the pathogenesis of ICC, particularly in patients harboring frequent ARID1A mutations.
Authors
- Jun Wu (ORCID: https://orcid.org/0000-0003-2515-6418)
- Muqing Cao (ORCID: https://orcid.org/0000-0002-0352-6548)
- Huiqin Zhu
- J. F. Hu (ORCID: https://orcid.org/0000-0002-8227-4544)
- Zimin Song (ORCID: https://orcid.org/0000-0002-0302-3502)
- Shunli Shen (ORCID: https://orcid.org/0000-0002-3133-3508)
- Xiaonan Wang (ORCID: https://orcid.org/0000-0003-3759-778X)
- Fang Liu (ORCID: https://orcid.org/0000-0002-6213-9572)
- Nan Yang (ORCID: https://orcid.org/0000-0003-4237-4513)
- Jie Yang (ORCID: https://orcid.org/0000-0001-5149-538X)
- Xing Xiong (ORCID: https://orcid.org/0000-0001-5728-150X)
- Shu Wang (ORCID: https://orcid.org/0000-0002-4241-3749)
- Jun Ying (ORCID: https://orcid.org/0000-0002-7693-4243)
- Qi Bian (ORCID: https://orcid.org/0000-0002-0102-7673)
- Xuxu Sun (ORCID: https://orcid.org/0000-0003-3730-4502)
Institutions
- Sun Yat-sen University (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai Cancer Institute (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Shanghai First People's Hospital (CN)
- Phoenix Contact (United States) (US)
Publication Details
- Journal
- Hepatology
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1097/hep.0000000000001422
- Citations
- 1
- Primary Topic
- Chromatin Remodeling and Cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.81