NME2 modulates HCC progression through 4EBP1 phosphorylation and autophagy regulation independent of mTOR
NME2 plays a crucial role in HCC development by modulating 4EBP1 phosphorylation and autophagy through an mTOR-independent pathway. Our research underscores NME2's significance as a potential therapeutic target in HCC, meriting further exploration of its underlying mechanisms and clinical applicability.
Authors
- Siqi Shan
- Wenwu Luo (ORCID: https://orcid.org/0000-0002-3842-7515)
- Hui Hou (ORCID: https://orcid.org/0000-0002-5568-4644)
- Rui Cheng (ORCID: https://orcid.org/0000-0002-5826-3044)
- Jiangming Chen (ORCID: https://orcid.org/0000-0002-9844-2370)
- Rong Wang (ORCID: https://orcid.org/0000-0003-1962-0165)
- Wei Chen (ORCID: https://orcid.org/0000-0002-0399-6216)
- Xiao Cui (ORCID: https://orcid.org/0000-0002-2456-5634)
- Fubao Liu (ORCID: https://orcid.org/0000-0003-1700-6890)
- Dachen Zhou
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- Second Affiliated Hospital of Anhui Medical University (CN)
- Third People's Hospital of Hefei (CN)
Publication Details
- Journal
- Hepatology Communications
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1097/hc9.0000000000000715
- Primary Topic
- Mechanisms of cancer metastasis
- Type
- article
- Field-Weighted Citation Impact
- 0.00