Roles of orexinergic and noradrenergic neuronal activity in ketamine-induced sedation: a study using an orexin-ataxin-3 transgenic rat model
Orexin-preserved noradrenergic activity supports the typical ketamine-induced sedation profile, highlighting their interactive role in modulating anesthetic depth.
Authors
- Kazuyoshi Hirota (ORCID: https://orcid.org/0000-0001-6936-0985)
- Yoshikazu Nikaido (ORCID: https://orcid.org/0000-0001-7912-6228)
- Hirotaka Kinoshita (ORCID: https://orcid.org/0000-0003-4490-3941)
- Mitsuru Tonosaki
- Daiki Takekawa (ORCID: https://orcid.org/0000-0003-4005-9536)
- Jumpei Saito (ORCID: https://orcid.org/0000-0003-4799-5562)
- Tetsuya Kushikata (ORCID: https://orcid.org/0000-0003-4263-0177)
Institutions
- Hirosaki University (JP)
- Hirosaki University Hospital (JP)
Publication Details
- Journal
- Journal of Anesthesia
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1007/s00540-025-03521-x
- Primary Topic
- Sleep and Wakefulness Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Ministry of Education, Culture, Sports, Science and Technology
- Hirosaki University
- University of Tsukuba
- Japan Society for the Promotion of Science