Biomimetic extracellular vesicles derived from chimeric antigen receptor monocytes to treat glioblastoma: An efficient and safe intranasal drug delivery nanoplatform
The findings of our study demonstrate that the intranasal administration of the facile and well-designed nanoplatform CAR-EVMs@DOX is an advanced drug delivery tactic for GBM therapy, with the potential for future clinical translation.
Authors
- Jianglin Zheng (ORCID: https://orcid.org/0000-0003-0616-2484)
- Kai Zhu (ORCID: https://orcid.org/0000-0002-9437-5254)
- Huitang Xia (ORCID: https://orcid.org/0000-0003-1568-2051)
- Tao Xin (ORCID: https://orcid.org/0000-0002-8797-3002)
- Xuan Wang (ORCID: https://orcid.org/0000-0001-6921-4005)
- Junjun Li (ORCID: https://orcid.org/0000-0002-7473-4918)
- Xudong Li (ORCID: https://orcid.org/0000-0002-6080-8605)
- Qihong Cheng
- Xiaobing Jiang (ORCID: https://orcid.org/0000-0002-9428-2381)
- Minjie Wang (ORCID: https://orcid.org/0000-0003-1345-7918)
- Shaojie Yu (ORCID: https://orcid.org/0000-0003-2202-3935)
- Zijie Zhou
Institutions
- Precision for Medicine (United States) (US)
- Wuhan Union Hospital (CN)
- Shandong Provincial QianFoShan Hospital (CN)
- First Affiliated Hospital of Jinan University (CN)
- Shandong First Medical University (CN)
- Union Hospital (CN)
Publication Details
- Journal
- Bioactive Materials
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1016/j.bioactmat.2025.05.032
- Citations
- 6
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 4.84