Reinforced Polymer–Nanoparticle Hydrogels for Subcutaneous and Sustained Delivery of Trastuzumab
In oncology, the advent of monoclonal antibody (mAb) therapeutics represents a breakthrough in various cancer diseases. However, these therapies often necessitate iterative hospital visits for intravenous infusion that alter patient quality of life and contribute to the chronic saturation of hospitals. Subcutaneous formulations of mAbs offer a promising alternative facilitating faster administration compared with traditional intravenous methods, while still maintaining the same dosing schedule and providing time-saving advantages. Here, an injectable mAb delivery platform using α-cyclodextrin (αCD)-reinforced polymer-nanoparticle hydrogels to perform subcutaneous mAb depots and delay their release is developed. By leveraging mAb-polymer electrostatic complexation, hyaluronic acid- and alginate-based injectable drug depots are formulated by simply mixing components that are generally regarded as safe. Trastuzumab is included as a clinically relevant therapeutic antibody. These formulations delayed mAb release both in vitro and in vivo mice models, with a similar pharmacokinetic performance to the clinically approved Herceptin SC (Roche) formulation composed of trastuzumab with recombinant human hyaluronidase (rHuPH20).
Authors
- Ellis Barbé
- Jacky G. Goetz (ORCID: https://orcid.org/0000-0003-2842-8116)
- Céline Mirjolet (ORCID: https://orcid.org/0000-0003-0047-9421)
- Giovanni Bovone (ORCID: https://orcid.org/0000-0002-8508-0737)
- Vincent Mittelheisser (ORCID: https://orcid.org/0000-0002-0456-3957)
- Sébastien Harlepp (ORCID: https://orcid.org/0000-0001-8891-7953)
- Olivier Lefèbvre (ORCID: https://orcid.org/0000-0001-9130-9174)
- Xavier Pivot (ORCID: https://orcid.org/0000-0003-3689-5013)
- Elia A. Guzzi (ORCID: https://orcid.org/0000-0003-0993-2536)
- Stéphane Bernhard (ORCID: https://orcid.org/0000-0002-6534-6905)
- Loı̈c J. Charbonnière (ORCID: https://orcid.org/0000-0003-0328-9842)
- Lorenza Garau Paganella (ORCID: https://orcid.org/0009-0002-8036-018X)
- Guillaume Jacquot
- Alexandre Detappe (ORCID: https://orcid.org/0000-0001-9364-1621)
- Mark W. Tibbitt (ORCID: https://orcid.org/0000-0002-4917-7187)
- Julien Draussin
- Luca Liebi
- Pedro Lopez Navarro (ORCID: https://orcid.org/0009-0008-3650-7117)
Institutions
- Centre National de la Recherche Scientifique (FR)
- Inserm (FR)
- Institut Pluridisciplinaire Hubert Curien (FR)
- ETH Zurich (CH)
- Institut de Cancérologie Strasbourg (FR)
- Centre Georges François Leclerc (FR)
- La Ligue Contre le Cancer (FR)
- Institut Polytechnique de Bordeaux (FR)
- Université de Strasbourg (FR)
Publication Details
- Journal
- Advanced Healthcare Materials
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1002/adhm.202404660
- Citations
- 4
- Primary Topic
- HER2/EGFR in Cancer Research
- Type
- article
- Field-Weighted Citation Impact
- 4.18