AURKA promotes angiogenesis in uveal melanoma via activation of the JAK2/STAT3/VEGFA signaling pathway
AURKA promoted UM progression by driving angiogenesis through the JAK2/STAT3/VEGFA signaling pathway. ART effectively inhibited the function of AURKA, offering a promising therapeutic strategy for UM. The synergistic effects of ART and knocking down AURKA further highlighted its potential as a novel anti-angiogenic therapy for UM.
Authors
- Yiqing Ji
- Qingyue Ma
- Qian Zhang (ORCID: https://orcid.org/0000-0001-7746-4231)
- Xintong Zhao (ORCID: https://orcid.org/0000-0002-9892-6922)
- Haowen Wang (ORCID: https://orcid.org/0009-0003-7994-0547)
- Wenjuan Luo (ORCID: https://orcid.org/0000-0003-3582-1215)
- Ke Lei (ORCID: https://orcid.org/0000-0002-2523-5530)
- Ying Sun
- Xiaodi Gao
- Yichong Liu (ORCID: https://orcid.org/0000-0002-6423-3706)
Institutions
- Qingdao University (CN)
- Affiliated Hospital of Qingdao University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1186/s12935-025-03836-5
- Citations
- 6
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 4.84
Funders
- National Natural Science Foundation of China