What about the heart — pediatric ALL survivors show cardiopulmonary limitations in the MinimALL Study
• Early diastolic dysfunction detected: despite normal EF and GLS, PCS exhibit an elevated E/E' septal ratio, reinforcing its role as a key marker for early cardiac changes.• Reduced exercise capacity linked to detraining: PCS show significantly lower <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow><mml:mover><mml:mi>V</mml:mi> <mml:mo>˙</mml:mo></mml:mover> <mml:msub><mml:mi>O</mml:mi> <mml:mn>2</mml:mn></mml:msub> <mml:mi>p</mml:mi> <mml:mi>e</mml:mi> <mml:mi>a</mml:mi> <mml:mi>k</mml:mi></mml:mrow> </mml:math> and peak heart rate, while stroke volume and pulmonary function remain preserved, suggesting detraining as a contributing factor.
Authors
- Axel Karow (ORCID: https://orcid.org/0000-0003-3963-7271)
- Sven Dittrich (ORCID: https://orcid.org/0000-0002-8455-3416)
- Nora Naumann‐Bartsch (ORCID: https://orcid.org/0000-0001-5606-9822)
- Isabelle Schoeffl
- Ferdinand Knieling (ORCID: https://orcid.org/0000-0002-3535-2626)
- Felix Huber (ORCID: https://orcid.org/0000-0002-3856-4018)
- Edward W. Wild (ORCID: https://orcid.org/0009-0003-9399-2108)
- N. A. Mueller
- Joachim Woelfle (ORCID: https://orcid.org/0000-0002-9132-6174)
- Felix Anderheiden
- Alexander Dierl
Institutions
- Friedrich-Alexander-Universität Erlangen-Nürnberg (DE)
- Universitätsklinikum Erlangen (DE)
- Leeds Beckett University (GB)
Publication Details
- Journal
- European Journal of Pediatrics
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1007/s00431-025-06243-0
- Citations
- 1
- Primary Topic
- Chemotherapy-induced cardiotoxicity and mitigation
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Universitätsklinikum Erlangen