Doxorubicin-mediated testicular toxicity is associated with dysregulated mTOR/Beclin-1 pathways, oxidative stress, inflammation and apoptosis in Wistar rats: preventive role of lutein
The findings of this study showed that lutein prevents doxorubicin-mediated testicular toxicity via modulation autophagic pathways accompanied with inhibition of oxidative stress, inflammation and apoptosis.
Authors
- Joseph Chimezie (ORCID: https://orcid.org/0000-0003-2637-2470)
- Taniyohwo Mamerhi Enaohwo
- Alexander Obidike Naiho
- Jerome Ndudi Asiwe (ORCID: https://orcid.org/0000-0001-5600-8288)
- LE Chris-Ozoko (ORCID: https://orcid.org/0000-0001-8092-4382)
- Blessing Oluwakemi Abe
- Oghenemarho Monalisa Ataikiru
- Jennifer Efe Jaiyeoba-Ojigho
- Sylvester Ifeakachukwu Okuepusu
- Favour Isioma Ikukaiwe
- Winnie Taiye Ogwu
- Godstime Jesukobiruo Ibada
Institutions
- University of Ibadan (NG)
- Delta State University (NG)
- Lead City University (NG)
Publication Details
- Journal
- Laboratory Animal Research
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1186/s42826-025-00249-3
- Citations
- 2
- Primary Topic
- Antioxidant Activity and Oxidative Stress
- Type
- article
- Field-Weighted Citation Impact
- 1.55