Long-Term Coronary Microvascular and Cardiac Dysfunction After Severe COVID-19 Hospitalization
In this study, patients with COVID-19 exhibited long-term reduced stress perfusion indicating CMD, along with declined left ventricular function by global longitudinal strain and global circumferential strain. Lack of variation in stress perfusion between patients with and without cardiovascular risk factors may suggest CMD due to severe COVID-19, warranting further investigation to elucidate mechanisms and guide potential therapies.
Authors
- Klara Lodin (ORCID: https://orcid.org/0009-0008-3759-5278)
- Jannike Nickander (ORCID: https://orcid.org/0000-0001-5659-8142)
- Peter Kellman (ORCID: https://orcid.org/0000-0002-9875-6070)
- Judith Bruchfeld (ORCID: https://orcid.org/0000-0001-5399-0982)
- Henrik Engblom (ORCID: https://orcid.org/0000-0001-6424-5646)
- Hui Xue (ORCID: https://orcid.org/0000-0002-4561-5530)
- Michael Runold (ORCID: https://orcid.org/0000-0001-7568-2278)
- Daniel Loewenstein
- Kenneth Caidahl (ORCID: https://orcid.org/0000-0002-5079-9696)
- Marcus Ståhlberg (ORCID: https://orcid.org/0000-0003-0319-6240)
- Rebecka Steffen Johansson
Institutions
- Microsoft (United States) (US)
- National Institutes of Health (US)
- Karolinska University Hospital (SE)
- Lund University (SE)
- Karolinska Institutet (SE)
- National Heart, Lung, and Blood Institute (US)
- Skåne University Hospital (SE)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.14411
- Citations
- 5
- Primary Topic
- Long-Term Effects of COVID-19
- Type
- article
- Field-Weighted Citation Impact
- 6.95