Safety of glucocorticoid dose reduction in microscopic polyangiitis: a multicentre REVEAL cohort study
Reducing GCs to ≤10 mg/day at 6 months was not linked to increased mortality, infection, or relapse, suggesting it may be a feasible intermediate target. However, more aggressive GC reduction per guidelines might be needed for further infection risk reduction. Individualised tapering with close monitoring remains crucial.
Authors
- Keiichiro Kadoba (ORCID: https://orcid.org/0000-0002-8242-9374)
- Naoko Ito (ORCID: https://orcid.org/0009-0009-2536-6571)
- Yohei Fujiki
- Mikihito Shoji
- Hirofumi Miyake (ORCID: https://orcid.org/0000-0001-5655-6356)
- Mochammad Hatta (ORCID: https://orcid.org/0000-0002-8456-4203)
- Motomu Hashimoto (ORCID: https://orcid.org/0000-0002-9241-060X)
- Ryosuke Hiwa (ORCID: https://orcid.org/0000-0001-6968-5712)
- Mayu Shiomi (ORCID: https://orcid.org/0009-0008-8992-1805)
- Ayana Okazaki
- Takuya Kotani (ORCID: https://orcid.org/0000-0003-2190-0780)
- Wataru Yamamoto (ORCID: https://orcid.org/0000-0002-0810-4221)
- Ryu Watanabe (ORCID: https://orcid.org/0000-0002-1089-5296)
- Shogo Matsuda (ORCID: https://orcid.org/0000-0002-8436-2046)
- Atsushi Manabe (ORCID: https://orcid.org/0000-0002-3264-8261)
- Yuichi Masuda
Institutions
- Kyoto University (JP)
- Tenri Hospital (JP)
- Osaka City University (JP)
- Kurashiki Central Hospital (JP)
- Yodogawa Christian Hospital (JP)
- Health Information Management (BE)
- Osaka University of Pharmaceutical Sciences (JP)
- The University of Osaka (JP)
Publication Details
- Journal
- Modern Rheumatology
- Published
- 2025-06-06
- DOI
- https://doi.org/10.1093/mr/roaf053
- Citations
- 1
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 1.52