Night shift work and lung cancer risk: a prospective cohort study with mediator analysis from the UK Biobank
This study suggests that night shift work, particularly when combined with smoking, is associated with an increased risk of lung cancer. The identification of potential mediators such as prostasin, ALPP and CEACAM5 provides insights into the underlying biological mechanisms. Future research should validate these findings and explore targeted prevention strategies for high-risk populations.
Authors
- Jie Liang (ORCID: https://orcid.org/0000-0002-6792-8941)
- Bo Cheng (ORCID: https://orcid.org/0000-0002-5066-007X)
- Juan He (ORCID: https://orcid.org/0000-0003-1566-6967)
- Xin Bi (ORCID: https://orcid.org/0000-0003-0677-2506)
- Zixun Wang (ORCID: https://orcid.org/0000-0003-0252-2737)
- Wenhua Liang (ORCID: https://orcid.org/0000-0002-1391-8238)
- Xian-Zhe Fan
- Cory J. Xian (ORCID: https://orcid.org/0000-0002-8467-2845)
- Kexin Chen (ORCID: https://orcid.org/0000-0003-4248-7681)
- Jianxing He (ORCID: https://orcid.org/0000-0003-1737-8192)
- Xiaohong Xie (ORCID: https://orcid.org/0000-0002-3426-4253)
- Xinyi Wu (ORCID: https://orcid.org/0000-0001-9475-3510)
- Yi Feng (ORCID: https://orcid.org/0000-0001-7998-656X)
- Xusen Zou
- Xiangyuan Zheng (ORCID: https://orcid.org/0009-0008-0417-0679)
Institutions
- First Affiliated Hospital of Guangzhou Medical University (CN)
- National Clinical Research (US)
- Guangzhou Institute of Dermatology (CN)
- State Key Laboratory of Respiratory Disease (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- SLEEP
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1093/sleep/zsaf159
- Citations
- 3
- Primary Topic
- Circadian rhythm and melatonin
- Type
- article
- Field-Weighted Citation Impact
- 2.74
Funders
- National Science Foundation