Cancer cell-derived migrasomes harboring ATF6 promote breast cancer brain metastasis via endoplasmic reticulum stress-mediated disruption of the blood-brain barrier
This study uncovered a pivotal role of cancer cell-derived in BCBM by harnessing ATF6-mediated ER stress to disrupt the BBB and promote metastasis, suggesting novel diagnostic and therapeutic strategies targeting migrasomes and migrasome cargo.
Authors
- Bo Fu (ORCID: https://orcid.org/0000-0002-6584-391X)
- Song Wang (ORCID: https://orcid.org/0000-0002-2338-5842)
- Guohao Gu
- Jianran Guo
- Anqi Zhang (ORCID: https://orcid.org/0000-0001-5128-2464)
- Jun Li (ORCID: https://orcid.org/0000-0002-7236-8088)
- Yan Dong (ORCID: https://orcid.org/0000-0002-6231-1942)
- Chen Shen (ORCID: https://orcid.org/0000-0001-8640-4492)
- Xinmiao Xian
- Wei Zhang (ORCID: https://orcid.org/0009-0000-4419-7691)
- Meng An (ORCID: https://orcid.org/0000-0003-2908-3199)
- Bingwu Yang
- Di Zhang (ORCID: https://orcid.org/0000-0001-5196-4633)
Institutions
- Precision for Medicine (United States) (US)
- Liaocheng People's Hospital (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- Cancer Biology and Medicine
- Published
- 2025-06-09
- DOI
- https://doi.org/10.20892/j.issn.2095-3941.2025.0014
- Citations
- 5
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 3.37
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Shandong Province