Deciphering meiotic chromatin organization by SYCP3

Chromatin structure during meiosis is different from somatic cells due to the assembly of the synaptonemal complex between homologous chromosome axes. However, genome-wide organizing principles of this meiosis-specific multiprotein complex remain mysterious despite intensive super-resolution imaging analysis. Here, we profiled chromatin occupancy of SYCP3, the key chromatin organizer of synaptonemal complex, in mouse spermatocytes, and showed its enrichment at open chromatin regions. Moreover, SYCP3 occupancy was largely inherited from the leptotene to pachytene stage, facilitated by transcription and fibrous assembly, and was enriched at specific SINE repeats. We also identified SYCP1-occupied regions mainly as a subpopulation of SYCP3-occupied regions with high cohesin enrichment. Collectively, our results demonstrate genome-wide profiling of SYCP3 in mouse meiosis and reveal that its occupancy is a dynamic process modulated by chromatin-related events.

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Publication Details

Journal
Nucleic Acids Research
Published
2025-06-06
DOI
https://doi.org/10.1093/nar/gkaf460
Citations
3
Primary Topic
DNA Repair Mechanisms
Type
article
Field-Weighted Citation Impact
2.42

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article

Deciphering meiotic chromatin organization by SYCP3

Gong‐Hong Wei, Liquan Zhou, Caifeng Fei, Ximiao He et al.
3 citations
Nucleic Acids Research
DNA Repair Mechanisms
2.42
article

Deciphering meiotic chromatin organization by SYCP3

Gong‐Hong Wei, Liquan Zhou, Caifeng Fei, Ximiao He, Wei Xia, Mengcheng Luo, Weibing Qin, Shimeng Guo, Yiran Zhang, Ying Yin, Honggang Li, Chengliang Xiong, Xiaozhao Liu
article en
3 citations

Abstract

Chromatin structure during meiosis is different from somatic cells due to the assembly of the synaptonemal complex between homologous chromosome axes. However, genome-wide organizing principles of this meiosis-specific multiprotein complex remain mysterious despite intensive super-resolution imaging analysis. Here, we profiled chromatin occupancy of SYCP3, the key chromatin organizer of synaptonemal complex, in mouse spermatocytes, and showed its enrichment at open chromatin regions. Moreover, SYCP3 occupancy was largely inherited from the leptotene to pachytene stage, facilitated by transcription and fibrous assembly, and was enriched at specific SINE repeats. We also identified SYCP1-occupied regions mainly as a subpopulation of SYCP3-occupied regions with high cohesin enrichment. Collectively, our results demonstrate genome-wide profiling of SYCP3 in mouse meiosis and reveal that its occupancy is a dynamic process modulated by chromatin-related events.

Nucleic Acids ResearchVol. 53(11)
Shanghai Medical College of Fudan University (CN), Wuhan University (CN), Fudan University Shanghai Cancer Center (CN), Children's Hospital of Chongqing Medical University (CN), Reproductive Genetics Institute (US), Huazhong University of Science and Technology (CN), Chongqing Medical University (CN)
National Natural Science Foundation of China, National Key Research and Development Program of China
Life in Land
Openalex Percentile: Top 11%
DNA Repair Mechanisms
2.42
DOIOpen Access PDFOpenAlex
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