Sensor Systems for Assessing Bacterial Susceptibility to Antibiotics

Excessive and sometimes inappropriate use of antibiotics leads to the emergence of multidrug-resistant (MDR) strains. Antibiotic-resistant pathogens are a major public health problem in routine clinical practice and have severe economic consequences due to increased treatment costs. Timely testing of antimicrobial susceptibility for bacterial infections ensures accurate prescribing, reduces treatment time, and helps minimize the spread of antibiotic-resistant infections. The main problem with antibiotic susceptibility testing is that there are not enough fast diagnostic tests to allow appropriateantibiotic prescribing at the point of care. Using traditional methods, determining the sensitivity of bacteria to antibiotics requires a minimum of 24 hours. Therefore, the development of express methods for determining antibacterial resistance, especially using biosensor systems, is relevant. The work provides a brief analysis of the problems of antibiotic sensitivity of bacteria in the world and presents the main mechanisms of its development, as well as describes the prospects of sensor methods for assessing the antibiotic resistance of bacteria.