Brain tau PET-based identification and characterization of subpopulations in patients with Alzheimer’s disease using deep learning-derived saliency maps
Our results suggest that tau tangles, as shown by SUVR, continue to accumulate even when cognitive function plateaus in AD patients, highlighting the advantages of PET in later disease stages. The differing relationships between cognition and tau deposition, and between gender, APOE4, and tau deposition, provide potential for subtype-specific treatments. Targeting gender-specific and genetic factors influencing tau deposition, as well as interventions aimed at tau's impact on cognition, may be effective.
Authors
- Tammie L.S. Benzinger (ORCID: https://orcid.org/0000-0002-8114-0552)
- Xiuying Wang (ORCID: https://orcid.org/0000-0001-7160-5929)
- Qi Ge (ORCID: https://orcid.org/0000-0001-6051-3017)
- Shuo Hu (ORCID: https://orcid.org/0000-0003-0998-8943)
- Yun Zhou (ORCID: https://orcid.org/0000-0001-9135-336X)
- Shaozhen Yan (ORCID: https://orcid.org/0000-0002-0315-7930)
- Jie Lu (ORCID: https://orcid.org/0000-0003-0425-3921)
- Yanxiao Li (ORCID: https://orcid.org/0000-0002-0600-8711)
- Jian Li (ORCID: https://orcid.org/0000-0003-0107-2869)
- Shuyu Li (ORCID: https://orcid.org/0000-0002-3459-6821)
- Wenjian Gu (ORCID: https://orcid.org/0009-0006-9671-1481)
- Manuel B. Graeber
Institutions
- The University of Sydney (AU)
- Central South University (CN)
- Capital Medical University (CN)
- Beijing Normal University (CN)
- ShanghaiTech University (CN)
- Mallinckrodt (United States) (US)
- United Imaging Healthcare (China) (CN)
- Xiangya Hospital Central South University (CN)
Publication Details
- Journal
- EJNMMI Physics
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1186/s40658-025-00761-4
- Citations
- 3
- Primary Topic
- Medical Imaging Techniques and Applications
- Type
- article
- Field-Weighted Citation Impact
- 4.08
Funders
- U.S. Department of Defense
- Alzheimer's Association
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Biogen
- University of Southern California
- Meso Scale Diagnostics
- Alzheimer's Disease Neuroimaging Initiative
- BioClinica
- Novartis Pharmaceuticals Corporation
- Northern California Institute for Research and Education
- Eisai
- Servier
- H. Lundbeck A/S
- IXICO
- National Institutes of Health
- Genentech
- Canadian Institutes of Health Research
- National Key Research and Development Program of China