Prehabilitation during neoadjuvant chemotherapy results in an enhanced immune response in esophageal adenocarcinoma tumors: A randomized controlled trial
We show that exercise training during NAC, which promotes higher levels of cardiorespiratory fitness than no exercise, is associated with increased frequencies of TILs and maturity of TLS. These data suggest that exercise during NAC enhances the immune system. Future studies are warranted to understand the clinical consequences of this.
Authors
- Nicola Annels (ORCID: https://orcid.org/0000-0002-6795-5616)
- Charles Rayner (ORCID: https://orcid.org/0000-0002-1934-4597)
- Izhar Bagwan
- Tyler Wooldridge (ORCID: https://orcid.org/0009-0000-7326-7556)
- Sunny Sunshine
- Nima Abbassi‐Ghadi
- Shaun R. Preston (ORCID: https://orcid.org/0000-0002-9547-0587)
- David B. Bartlett (ORCID: https://orcid.org/0000-0001-7838-898X)
- Javed Sultan (ORCID: https://orcid.org/0000-0001-5343-3641)
- Adam E. Frampton (ORCID: https://orcid.org/0000-0002-1392-2755)
- Julie Hunt (ORCID: https://orcid.org/0009-0002-4678-8596)
- Tadd Seymour
- David King
- Sophie Allen (ORCID: https://orcid.org/0000-0002-0357-6860)
Institutions
- Royal Surrey County Hospital (GB)
- Salford Royal NHS Foundation Trust (GB)
- University of Surrey (GB)
- Heriot-Watt University (GB)
- Royal Surrey NHS Foundation Trust (GB)
Publication Details
- Journal
- Journal of sport and health science/Journal of Sport and Health Science
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1016/j.jshs.2025.101063
- Citations
- 6
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 12.04