<scp>IgG2b</scp> enhances alloantibodies to stored red blood cells
These findings provide insight into how preexisting antibodies in transfusion recipients increase the risk of future alloimmunization events. Considering that FcγRIV on dendritic cells is also required for IgG2c-enhanced alloantibodies, this pathway represents a potential interventional target for the reduction of RBC alloimmunization risk in transfusion recipients.
Authors
- Krystalyn E. Hudson (ORCID: https://orcid.org/0000-0001-5663-9290)
- Annie Qiu
- Flavia Dei Zotti
- Shwatina Jagnarine
- Emmalene Kyritsis
Institutions
- Columbia University Irving Medical Center (US)
Publication Details
- Journal
- Transfusion
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1111/trf.18306
- Citations
- 1
- Primary Topic
- Blood groups and transfusion
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- National Heart, Lung, and Blood Institute