Predictors of Mortality in Medical ICU Patients: A Retrospective Study in a Tertiary Care Center in Jordan

<b>Background/Objectives</b>: This study aims to investigate ICU mortality rates and to identify predictors of ICU mortality, focusing on clinical and demographic variables, including age, comorbidities, hemoglobin and creatinine values, intubation in the Emergency department, and Glasgow Coma Scale (GCS) and APACHE II scores at presentation in the Emergency department, and how these factors influence patients' clinical outcomes. <b>Methods</b>: This retrospective observational cross-sectional study analyzed patients admitted to the Jordan University Hospital (JUH) ICU from 1 January 2022 to 31 December 2023. A total of 1323 patients were included, with a mean age of 65 ± 17 years, of whom 442 (34%) died during their ICU stay. <b>Results</b>: A delay of 6 h or more in ICU admission was reported for 77% of the participants. Mortality rates were significantly lower among patients admitted to the ICU through the Emergency department (32%) compared to those transferred from other wards (41%) (<i>p</i> = 0.003). Higher mortality rates were observed among patients on vasopressors and those intubated in the Emergency department, with lower median hemoglobin (Hb) levels, higher APACHE II scores, and pneumonia as the main diagnosis or urosepsis as the secondary diagnosis (<i>p</i> < 0.001). <b>Conclusions</b>: This study identified predictors of mortality in a medical ICU at a tertiary hospital in Jordan.