Evaluation of immunohistochemical expression of mismatch repair genes product in colorectal carcinoma and its correlation with clinicopathological parameters in a sample of Iraqi patients

This study shows that MSI has a highly significant association with young age and mucinous carcinoma. The combined loss of MLH1 and MSH2 was statistically and highly significant than other combinations. IHC is a simple process to detect MSI status and guide oncologists in determining treatment options such as conventional chemotherapy or immunotherapy.