Predictors of disease burden in patients with untreated transthyretin amyloid cardiomyopathy and their caregivers: a post hoc analysis of an international survey
Our analysis showed that heart failure symptoms, weakness, especially in the legs, older age, and female sex, are independent predictors of higher disease burden in patients with ATTR-CM. A higher caregiver burden was best predicted by poorer health status in the patient, even in the presence of potential moderators. Implementing strategies to reduce the physical symptoms experienced by patients with ATTR-CM may help to reduce their burden, and that experienced by caregivers.
Authors
- Ronnie Wang
- Carmen Munteanu
- Mónica Inês (ORCID: https://orcid.org/0000-0003-3631-4995)
- Kristen Hsu (ORCID: https://orcid.org/0000-0003-2106-3652)
- Nisith Kumar
- Lucia Ponti (ORCID: https://orcid.org/0000-0001-8255-5672)
- Eduardo Villacorta (ORCID: https://orcid.org/0000-0003-0486-1740)
- Nicolas Verheyen (ORCID: https://orcid.org/0000-0001-7414-4056)
- Denis Keohane
- Thibaud Damy (ORCID: https://orcid.org/0000-0003-4058-3848)
- Francesco Cappelli (ORCID: https://orcid.org/0000-0002-1622-0732)
Institutions
- Pfizer (United States) (US)
- University of Urbino (IT)
- Medical University of Graz (AT)
- Complejo Hospitalario de Salamanca (ES)
- Amyloidosis Foundation (US)
- Azienda Ospedaliero-Universitaria Careggi (IT)
- Hôpitaux Universitaires Henri-Mondor (FR)
Publication Details
- Journal
- Frontiers in Cardiovascular Medicine
- Published
- 2025-06-09
- DOI
- https://doi.org/10.3389/fcvm.2025.1595797
- Citations
- 1
- Primary Topic
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Pfizer