Insights into immune-related adverse events in colorectal cancer patients receiving neoadjuvant immunotherapy: findings from a multicenter registry study
Neoadjuvant immunotherapy combined with chemoradiotherapy demonstrates a favorable safety profile, with most irAEs being manageable. The findings support the clinical feasibility of combined regimens in CRC treatment, emphasizing the need for individualized management and extended follow-up for late-onset or chronic irAEs.
Authors
- Liting Sun (ORCID: https://orcid.org/0000-0003-2000-9638)
- Hongwei Yao (ORCID: https://orcid.org/0000-0003-3995-6520)
- Lei Zhou (ORCID: https://orcid.org/0000-0002-3995-1087)
- Ganbin Li (ORCID: https://orcid.org/0000-0002-2576-1100)
- Xiaoyuan Qiu (ORCID: https://orcid.org/0000-0003-1494-9068)
- Xiaoyu Xie (ORCID: https://orcid.org/0000-0002-1852-8546)
- Chentong Wang (ORCID: https://orcid.org/0009-0006-1590-6675)
- Yang Gong (ORCID: https://orcid.org/0000-0001-5294-6437)
- Guole Lin (ORCID: https://orcid.org/0000-0001-6225-3028)
- Han Chen (ORCID: https://orcid.org/0000-0002-7513-034X)
- Wei Zhang (ORCID: https://orcid.org/0000-0003-3094-9711)
- Yang An (ORCID: https://orcid.org/0000-0002-9335-6975)
- Weijie Chen (ORCID: https://orcid.org/0000-0002-4559-6317)
- Yuping Zhu
- Xiaojian Wu (ORCID: https://orcid.org/0000-0001-5610-2530)
- Aiping Zhou (ORCID: https://orcid.org/0000-0003-1632-837X)
- Quan Wang (ORCID: https://orcid.org/0000-0003-1051-8287)
- Jiaolin Zhou (ORCID: https://orcid.org/0000-0003-2020-5161)
- Xiao Zhang
- Guanyu Yu (ORCID: https://orcid.org/0000-0001-5416-3559)
- Tao Jin-hua (ORCID: https://orcid.org/0000-0002-0814-2455)
Institutions
- Sun Yat-sen University (CN)
- Second Military Medical University (CN)
- Capital Medical University (CN)
- Jilin University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- China-Japan Friendship Hospital (CN)
- Peking Union Medical College Hospital (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Zhejiang Cancer Hospital (CN)
- Changhai Hospital (CN)
- First Hospital of Jilin University (CN)
- Beijing Friendship Hospital (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1529637
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.09
Funders
- Peking Union Medical College Hospital