Lower respiratory tract co-infection of Streptococcus pneumoniae and respiratory syncytial virus shapes microbial landscape and clinical outcomes in children
Our findings show that RSV co-infection exacerbates SP-induced LRTI microbiota disorder and disease severity. This study may help us to better understand the characteristics of SP-RSV interaction and provide direction for the pathogen diagnosis of LRTI.
Authors
- Xiaoran Yu (ORCID: https://orcid.org/0000-0002-8669-0529)
- Yiqin Song
- Adong Shen (ORCID: https://orcid.org/0000-0001-6141-0917)
- Tingting Jiang (ORCID: https://orcid.org/0000-0001-8755-2147)
- Xuemei Yang (ORCID: https://orcid.org/0000-0003-4005-978X)
- Xiaoxuan Yang (ORCID: https://orcid.org/0000-0002-2553-2631)
- Jing Bi (ORCID: https://orcid.org/0009-0002-1838-5802)
- Xi Zeng (ORCID: https://orcid.org/0009-0008-6079-5008)
- Jie Yu (ORCID: https://orcid.org/0000-0001-6345-2096)
- Lin Sun (ORCID: https://orcid.org/0000-0003-0458-2311)
- He Tang
Institutions
- Peking University (CN)
- Zhengzhou University (CN)
- Zhengzhou Children's Hospital (CN)
- Beijing Children’s Hospital (CN)
- Baoding People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-06-09
- DOI
- https://doi.org/10.3389/fcimb.2025.1593053
- Citations
- 3
- Primary Topic
- Respiratory viral infections research
- Type
- article
- Field-Weighted Citation Impact
- 4.06
Funders
- National Natural Science Foundation of China
- Beijing Municipal Health Commission