Astragalus membranaceus extract attenuates ulcerative colitis by integrating multiomics and the PI3K/AKT signaling pathway
Our study demonstrated that the AM extract effectively alleviated UC. The extract was shown to modulate microbial dysbiosis triggered by DSS and promote the generation of beneficial metabolites. Subsequent analyses confirmed that these effects are mediated through activation of the PI3K/AKT signaling pathway. Collectively, these findings offer novel insights into treatment strategies for UC.
Authors
- Mingjiang Mao (ORCID: https://orcid.org/0009-0006-2226-1342)
- Qingling Meng (ORCID: https://orcid.org/0000-0001-7844-5075)
- Fan Song (ORCID: https://orcid.org/0000-0001-7359-2519)
- Chao Shen-Tu
- Xiaofeng Yuan (ORCID: https://orcid.org/0000-0002-9048-1754)
- Yunjia Tang (ORCID: https://orcid.org/0000-0002-3375-1340)
- Jiaying Zhu
Institutions
- Zhejiang Chinese Medical University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-06-09
- DOI
- https://doi.org/10.3389/fphar.2025.1585748
- Citations
- 2
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 3.11
Funders
- National Natural Science Foundation of China
- Zhejiang Chinese Medical University