A multi-omics study of magnesium sulfate to improve prognosis in sepsis-related encephalopathy: integrating clinical data-driven network pharmacology
Magnesium sulfate use correlates with improved SAE survival, particularly those with comorbid chronic obstructive pulmonary disease and acute kidney injury, and using vasoconstrictors, likely through multi-target modulation of inflammatory response and immune regulation. Prospective studies are needed for validation.
Authors
- Yao Kong (ORCID: https://orcid.org/0009-0001-1479-9672)
- Liang Shi (ORCID: https://orcid.org/0000-0001-7423-7172)
- Hao Chen (ORCID: https://orcid.org/0000-0001-8058-6352)
- Meng Zhang (ORCID: https://orcid.org/0000-0003-3643-9501)
- Bin Chen (ORCID: https://orcid.org/0000-0002-1114-7759)
- Hong Ji (ORCID: https://orcid.org/0000-0003-4896-7213)
- Rui Feng (ORCID: https://orcid.org/0000-0003-0678-7740)
- Yanghao Tai
Institutions
- Shanxi Medical University (CN)
- Shanxi Academy of Medical Sciences (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-06-09
- DOI
- https://doi.org/10.3389/fcimb.2025.1607586
- Citations
- 1
- Primary Topic
- Intensive Care Unit Cognitive Disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.55
Funders
- Natural Science Foundation of Shanxi Province
- ShanXi Science and Technology Department