Porphyromonas gingivalis-induced periodontitis promotes neuroinflammation and neuronal loss associated with dysfunction of the brain barrier
Periodontitis aggravated neuroinflammation and neuronal loss which was associated with tau hyperphosphorylation. The impaired meningeal lymphatic vessels (MLV) and disrupted BBB affected the brain barrier function, further inhibiting the clearance of pathogenic substances and enhancing immune cell infiltration in periodontitis mice. These results indicated that brain barrier dysfunction may be the link between periodontitis and cognitive impairment.
Authors
- Che Qiu
- Wei Zhou (ORCID: https://orcid.org/0000-0003-3989-4198)
- Zhongchen Song (ORCID: https://orcid.org/0000-0002-9249-7645)
- Xia Zhao
- Yiting Jiang (ORCID: https://orcid.org/0009-0001-0434-5204)
- Lina Xu (ORCID: https://orcid.org/0000-0003-1785-382X)
- Zhiyan He (ORCID: https://orcid.org/0000-0002-6242-6563)
- Hui Shen (ORCID: https://orcid.org/0000-0003-1859-4559)
Institutions
- Shanghai Jiao Tong University (CN)
- Wenzhou Medical University (CN)
- National Clinical Research Center for Digestive Diseases (CN)
- Shanghai Ninth People's Hospital (CN)
- Zhejiang Taizhou Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-06-09
- DOI
- https://doi.org/10.3389/fcimb.2025.1559182
- Citations
- 7
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 6.36