Decoding ferroptosis in ischemic stroke: key genes and the therapeutic potential of acupuncture
The ferroptosis pathway, autophagy-animal pathway, apoptosis pathway, HIF-1 signaling pathway, and longevity-regulating pathway were identified as crucial pathways associated with ferroptosis in cerebral ischemic stroke. Bioinformatics analysis and RT-qPCR suggested that FTH1, SLC40A1, NRAS, CD82, and PTPN18 might serve as potential key targets underlying the antiferroptotic effects of acupuncture on ischemic stroke.
Authors
- Shuping Zhu
- Chunzhi Tang
- Qizhang Wang (ORCID: https://orcid.org/0000-0001-9529-976X)
- Chunxiao Wu (ORCID: https://orcid.org/0000-0002-8637-5545)
- Zhirui Xu
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Shenzhen Pingle Orthopedic Hospital (CN)
Publication Details
- Journal
- Frontiers in Aging Neuroscience
- Published
- 2025-06-09
- DOI
- https://doi.org/10.3389/fnagi.2025.1506276
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52
Funders
- National Natural Science Foundation of China
- China Postdoctoral Science Foundation
- Natural Science Foundation of Guangdong Province
- Guangzhou University of Chinese Medicine
- Guangzhou University
- Sanming Project of Medicine in Shenzhen