The application of multimodal ultrasound examination in the differential diagnosis of benign and malignant breast lesions of BI-RADS category 4

(1) CEUS and SWE provide diagnostic information about the microvascular perfusion and tissue stiffness of lesions, respectively, which can assist in the differentiation of benign from malignant breast tumors by conventional US and improve the sensitivity, specificity and accuracy of diagnosis, especially for US BI-RADS 4a breast lesions. (2) The combined use of CEUS and SWE in conventional US enhance the overall diagnostic performance with respect to breast lesions, with the best sensitivity and specificity and the highest diagnostic efficacy. The use of US + CEUS + SWE is beneficial for further differentiating benign and malignant breast lesions according to the US BI-RADS 4, thereby reducing unnecessary biopsies or surgeries.