Itaconate and obesity-related hormones promote tumor progression – new insights on metabolic dysfunction in early-onset colon cancer
Obesity-related hormones can increase itaconate production in M2-like macrophages. <i>IRG1</i> expression and the NOTCH4-GATA4-IRG1 pathway are associated with EOCC, BMI, and patient survival. As a macrophage metabolite affecting inflammation, itaconate may have a particular immunotherapeutic role in patients with EOCC.
Authors
- Katharina M. Scheurlen (ORCID: https://orcid.org/0000-0003-4169-9041)
- Robert J. Beal
- Susan Galandiuk (ORCID: https://orcid.org/0000-0001-9994-5263)
- Julia H. Chariker (ORCID: https://orcid.org/0000-0001-6805-7220)
- Jacob Hallion
- Adrian T. Billeter (ORCID: https://orcid.org/0000-0001-8724-4793)
- Eric C. Rouchka (ORCID: https://orcid.org/0000-0003-3487-6572)
- Mary A. Parks
- Jeannette T. Bensen (ORCID: https://orcid.org/0000-0003-4972-0087)
- Andrew B. Littlefield
- Jeremy Gaskins (ORCID: https://orcid.org/0000-0002-6284-3404)
- Dylan L. Snook (ORCID: https://orcid.org/0000-0003-3172-4071)
- Anne Macleod (ORCID: https://orcid.org/0000-0002-2712-536X)
- Eliah Hiken
Institutions
- University of North Carolina at Chapel Hill (US)
- University of Louisville (US)
- Rice Institute (US)
- St. Claraspital (CH)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1572985
- Citations
- 3
- Primary Topic
- Cancer, Lipids, and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 2.81
Funders
- University of Louisville
- National Institutes of Health
- University of North Carolina at Chapel Hill
- National Heart, Lung, and Blood Institute
- National Institute of Mental Health
- National Institute on Drug Abuse
- National Human Genome Research Institute
- NIH Office of the Director
- National Cancer Institute
- National Institute of Neurological Disorders and Stroke
- Common Fund