Dual roles of Anisakis pegreffii proteins in macrophage immune dynamics
This study shows that <i>A. pegreffii</i> induces a dual-pronged immune response: ABP exacerbates inflammation, while glycoproteins suppress it. This highlights glycoproteins' potential as therapeutic targets for modulating parasitic immunopathology and inflammatory diseases. The analysis of ABP and glycoprotein - induced immune responses provides key insights into Anisakiasis pathogenesis and may help develop new treatments.
Authors
- Sarah Alsobaie (ORCID: https://orcid.org/0000-0002-1707-6461)
- Minhao Zeng
- Fahad M. Aldakheel (ORCID: https://orcid.org/0000-0001-8047-8650)
- Mourad A. M. Aboul‐Soud (ORCID: https://orcid.org/0000-0001-9395-0563)
- Shan Li (ORCID: https://orcid.org/0000-0002-0824-251X)
- Xiaoxu Wang (ORCID: https://orcid.org/0000-0002-4291-0729)
- Weibin Liu (ORCID: https://orcid.org/0000-0002-9349-039X)
Institutions
- Jiujiang University (CN)
- King Saud Medical City (SA)
- King Saud University (SA)
- Huzhou Normal University (CN)
- Jiangsu University of Science and Technology (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1595093
- Citations
- 1
- Primary Topic
- Parasite Biology and Host Interactions
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- King Saud University
- Central South University