Causal associations between gut microbiota, metabolites, and idiopathic normal pressure hydrocephalus: a two‑sample Mendelian randomization study
Our MR analysis provides evidence supporting the causality of certain gut microbial taxa and their derived metabolites on INPH. This underscores the potential for interventions targeting specific gut microbiota and derived metabolites in the treatment and prevention of INPH.
Authors
- Xianfeng Li (ORCID: https://orcid.org/0000-0001-8549-537X)
- Wencai Wang (ORCID: https://orcid.org/0009-0004-5673-1643)
- Menghao Liu (ORCID: https://orcid.org/0000-0002-5284-0146)
- Yongqiang Zhao (ORCID: https://orcid.org/0000-0002-1013-5983)
- Zun Wang (ORCID: https://orcid.org/0000-0002-7457-4336)
- Wei Ye (ORCID: https://orcid.org/0009-0003-7331-8650)
- Luyao Ma
Institutions
- Harbin Medical University (CN)
- Fuyang City People's Hospital (CN)
- Fuyang Maternity and Child Health Care Hospital (CN)
- Second Affiliated Hospital of Harbin Medical University (CN)
- Juntendo University Hospital (JP)
- Fuyang Second People's Hospital (CN)
Publication Details
- Journal
- BMC Neurology
- Published
- 2025-06-09
- DOI
- https://doi.org/10.1186/s12883-025-04187-4
- Primary Topic
- Cerebrospinal fluid and hydrocephalus
- Type
- article
- Field-Weighted Citation Impact
- 0.00