Natriuretic peptides modulate monocyte-derived Langerhans cell differentiation and promote a migratory phenotype
These findings demonstrate that NPR1 activation promotes a migratory LC phenotype, highlighting the role of neuropeptides in shaping cutaneous immune responses. The reduced number of LCs in AD skin suggests a potential link between neuropeptide signaling and disease pathology.
Authors
- Andrea Szegedi (ORCID: https://orcid.org/0000-0003-2109-9014)
- Magdolna Szántó (ORCID: https://orcid.org/0000-0002-7714-7065)
- Attila Gábor Szöllősi (ORCID: https://orcid.org/0000-0001-6046-8236)
- Tünde Fekete (ORCID: https://orcid.org/0000-0002-5415-1336)
- István Rebenku (ORCID: https://orcid.org/0000-0002-4959-7587)
- Szabolcs Muzsai (ORCID: https://orcid.org/0000-0002-0073-2194)
- Zsófia Pénzes (ORCID: https://orcid.org/0000-0002-3566-8532)
- Dorottya Horváth (ORCID: https://orcid.org/0000-0002-1387-241X)
- Petra Molnár (ORCID: https://orcid.org/0000-0002-3027-3777)
- Zsolt Dajnoki (ORCID: https://orcid.org/0000-0002-7787-1002)
- György Vereb (ORCID: https://orcid.org/0000-0003-2157-3265)
- Kitti Pázmándi (ORCID: https://orcid.org/0000-0001-7709-6707)
- Attila Bácsi (ORCID: https://orcid.org/0000-0002-2311-2975)
Institutions
- University of Debrecen (HU)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-06-09
- DOI
- https://doi.org/10.3389/fimmu.2025.1593141
- Citations
- 3
- Primary Topic
- Infant Nutrition and Health
- Type
- article
- Field-Weighted Citation Impact
- 3.36
Funders
- Magyar Tudományos Akadémia
- Debreceni Egyetem
- National Research, Development and Innovation Office