Ovarian transcriptome analyses indicate that weak juvenile hormone signaling underlies the molecular basis of oogenesis deficiencies in mosquitoes
Our results suggest that epoxidase deficiency leads to a reduction in JH signaling that has significant effects on Ae. aegypti ovarian transcriptome profiles. Ecdysteroid titers are dysregulated in the mutants, leading to a significant delay in the expression of vitelline membrane genes and other transcripts. We discovered changes in the expression of 230 long non-coding RNAs (lncRNAs) that may play an important role in the regulation of ovarian genes.
Authors
- Marcela Nouzová (ORCID: https://orcid.org/0000-0002-4562-1383)
- Martin Moos (ORCID: https://orcid.org/0000-0003-3930-3132)
- Martin Kolísko (ORCID: https://orcid.org/0000-0003-0600-1867)
- Fernando G. Noriega (ORCID: https://orcid.org/0000-0001-8628-5374)
- Houda Ouns Maaroufi (ORCID: https://orcid.org/0000-0002-6178-1037)
- Petra Berková
- Monika M Wiśniewska (ORCID: https://orcid.org/0000-0003-1530-7833)
Institutions
- Florida International University (US)
- University of South Bohemia in České Budějovice (CZ)
- Institute of Entomology (CZ)
- Institute of Parasitology (CZ)
- Czech Academy of Sciences, Biology Centre (CZ)
Publication Details
- Journal
- BMC Biology
- Published
- 2025-06-08
- DOI
- https://doi.org/10.1186/s12915-025-02266-z
- Citations
- 2
- Primary Topic
- Neurobiology and Insect Physiology Research
- Type
- article
- Field-Weighted Citation Impact
- 1.82
Funders
- Grantová Agentura České Republiky
- National Institutes of Health