The impact of GnRH agonists on endometrial immune cells in patients with adenomyosis: a prospective cohort study
Women with infertility and adenomyosis showed a similar endometrial immune profile as women with RPL and RIF. The beneficial effect of GnRH-a prior to FET in women with adenomyosis may be mediated through effects on monocyte subpopulations. Based on the high prevalence of elevated uNK cells in patients with adenomyosis, we suggest testing women with adenomyosis undergoing ART before FET.
Authors
- Katharina Feil (ORCID: https://orcid.org/0000-0002-4566-712X)
- Beata Seeber (ORCID: https://orcid.org/0000-0002-8224-4126)
- Anna Lena Zippl (ORCID: https://orcid.org/0000-0002-6994-892X)
- Christiana Kyvelidou (ORCID: https://orcid.org/0000-0001-6907-1542)
- Patrick Rockenschaub (ORCID: https://orcid.org/0000-0002-6499-7933)
- Bettina Toth
- Elisabeth Reiser (ORCID: https://orcid.org/0000-0002-7952-1284)
- Monika Frank
- Stefanie Schuchter
- Anne-Sophie Braun
- Elisa Gapp
Institutions
- Innsbruck Medical University (AT)
Publication Details
- Journal
- BMC Medicine
- Published
- 2025-06-08
- DOI
- https://doi.org/10.1186/s12916-025-04162-3
- Citations
- 3
- Primary Topic
- Endometriosis Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 5.09