Transcriptional landscape of pleural mesothelioma patients in relation to NF2 gene mutational status
NF2 mutations influence the tumor microenvironment, transcriptional landscape, and predicted therapeutic response in PM, underscoring their potential as prognostic biomarkers. These findings support tailored therapeutic strategies targeting NF2-related pathways, including Hippo signaling and cytokine modulation.
Authors
- Diego A. Bonilla (ORCID: https://orcid.org/0000-0002-2634-1220)
- Hui‐Mei Tsao (ORCID: https://orcid.org/0009-0000-9442-8638)
- Rafael Parra‐Medina (ORCID: https://orcid.org/0000-0002-8428-5837)
- Alejandro Mejía‐García (ORCID: https://orcid.org/0000-0002-5515-9057)
- Alba Lucía Cómbita (ORCID: https://orcid.org/0000-0001-6295-7316)
- Carlos A. Orozco (ORCID: https://orcid.org/0000-0002-7256-0942)
- Ricardo Brugés-Maya
Institutions
- Universidad de La Sabana (CO)
- University of the Basque Country (ES)
- Instituto Nacional de Cancerología (CO)
- Fundación Universitaria de Ciencias de la Salud (CO)
- McGill University (CA)
Publication Details
- Journal
- Journal of the Egyptian National Cancer Institute
- Published
- 2025-06-08
- DOI
- https://doi.org/10.1186/s43046-025-00284-0
- Citations
- 2
- Primary Topic
- Occupational and environmental lung diseases
- Type
- article
- Field-Weighted Citation Impact
- 3.04