Influence of Dalargin on the hematological indices in mice with experimental ulcerative colitis

The low effectiveness of existing methods of treatment for ulcerative colitis provides the necessity of the implementation of new treatment methods. The corrective effect of dalargin has been shown in mice with ulcerative colitis, but the mechanism of drug action requires further investigation. In this regard, the study of the dalargin effect on the dynamics of hematological indices in mice with ulcerative colitis is of undoubted interest. Ulcerative colitis in mice was simulated by replacing drinking water with a 5% solution of sodium dextran sulfate for 5 days. A decrease in the Krebs index, an increase in the leukocyte index, an index of the ratio of neutrophils to monocytes and an index of the ratio of lymphocytes to monocytes under the influence of dalargin (100 mcg/kg subcutaneously for 7 days) were shown in mice with experimental ulcerative colitis on the 5th day, as well as a decrease in the index of the ratio of lymphocytes and monocytes on the 7th day. The corrective effect of dalargin on hematological indices in mice with ulcerative colitis is higher than that of sulfasalazine.