The results of the use of platelet-rich plasma in surgical practice (review of the evidence base)

The aim of the study is to review the evidence base on the use of platelet-rich plasma in surgical practice for long-term non-healing wounds and trophic ulcers. Materials and methods: A systematic methodology was used in the work. An electronic search was conducted in the Elibrary, the Cochrane Library, the PubMed database of medical and biological publications. At the same time, filters designed to identify systematic reviews were applied. An additional manual search was performed using the snowballing methodology. Results: The analysis of thirteen secondary scientific papers showed that the subject of research were chronic wounds and trophic ulcers of various etiologies and localization in six systematic reviews, diabetic foot – in five and trophic ulcers in chronic venous insufficiency – in two ones., Calculations were performed based on the results of randomized studies in eight out of the thirteen systematic meta-analytical reviews, and on the results of both randomized and non-randomized studies – in five ones (Level of Evidence-1 and Level of Evidence-2, respectively). A consistent expert analysis was made only in one out of the secondary scientific papers. The conclusions of the meta-analyses are consistent. Platelet-rich plasma improves the healing of long-term non-healing wounds and trophic ulcers of various etiologies. At the same time, the quality of primary research on the analyzed topic is low, which can compromise the results of meta-analyses. Conclusion: The highest efficacy and efficiency of the use of platelet-rich plasma has been noted in the treatment of long-term non-healing wounds and trophic ulcers. Questions of the preferred method of its use in the area of pathological changes in soft tissues require further study.