Clinical case of acquired inhibitory form of hemophilia a in an elderly patient

The formation of circulating autoantibodies capable of inhibiting factors of the blood coagulation system is accompanied by the occurrence of spontaneous and/or post-traumatic bleeding in patients without a history of previous disorders of the hemostatic system. One of the reasons for the development of such conditions is acquired hemophilia. Aim: Identification of the mechanisms of development of the acquired inhibitory form of hemophilia A in elderly patients using the example of our own clinical observation. Material and methods: Analysis of a clinical case and analysis of current scientific literature. Results: The presented clinical case allowed us to study the pathogenesis, principles of diagnosis and treatment of acquired coagulopathy. Conclusions: Knowledge about the development mechanisms and features of the course of the acquired inhibitory form of hemophilia A should help the clinician in the early diagnosis of this coagulopathy and, as a consequence, the timely initiation of treatment aimed at preserving the patient’s life.

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Publication Details

Journal
Journal of Volgograd State Medical University
Published
2025-06-08
DOI
https://doi.org/10.19163/1994-9480-2025-22-1-164-166
Primary Topic
Hemophilia Treatment and Research
Type
article
Field-Weighted Citation Impact
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article

Clinical case of acquired inhibitory form of hemophilia a in an elderly patient

Liliya M. Salimova, Alsu F. Molostvova
Journal of Volgograd State Medical University
Hemophilia Treatment and Research
article

Clinical case of acquired inhibitory form of hemophilia a in an elderly patient

Liliya M. Salimova, Alsu F. Molostvova
article en

Abstract

The formation of circulating autoantibodies capable of inhibiting factors of the blood coagulation system is accompanied by the occurrence of spontaneous and/or post-traumatic bleeding in patients without a history of previous disorders of the hemostatic system. One of the reasons for the development of such conditions is acquired hemophilia. Aim: Identification of the mechanisms of development of the acquired inhibitory form of hemophilia A in elderly patients using the example of our own clinical observation. Material and methods: Analysis of a clinical case and analysis of current scientific literature. Results: The presented clinical case allowed us to study the pathogenesis, principles of diagnosis and treatment of acquired coagulopathy. Conclusions: Knowledge about the development mechanisms and features of the course of the acquired inhibitory form of hemophilia A should help the clinician in the early diagnosis of this coagulopathy and, as a consequence, the timely initiation of treatment aimed at preserving the patient’s life.

Journal of Volgograd State Medical UniversityVol. 22(1)
Kazan State Medical University (RU), City Clinical Hospital (RU)
Openalex Percentile: Top 83%
Hemophilia Treatment and Research
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