<i>Enterococcus faecalis</i> hijacks FABP2 to activate quorum-sensing signals and aggravate Crohn’s disease by inducing gut dysbiosis
This study reveals a novel mechanism by which commensal bacteria use host-derived FABP2 to drive dysbiosis and worsen CD pathology. Targeting the FABP2-EF3041 axis may offer new diagnostic and therapeutic avenues for managing CD.
Authors
- Xi Huang (ORCID: https://orcid.org/0000-0002-1898-6918)
- Ji Qi (ORCID: https://orcid.org/0000-0001-7135-0524)
- Xiaoli Jiang (ORCID: https://orcid.org/0000-0003-4628-3256)
- Guoping Zhao (ORCID: https://orcid.org/0000-0002-7621-6620)
- Wenying Zhao (ORCID: https://orcid.org/0000-0001-8774-144X)
- Sanhong Liu (ORCID: https://orcid.org/0000-0002-8695-0343)
- Kaiwen Yu (ORCID: https://orcid.org/0000-0002-6050-8477)
- Zerong Lu
- Qijun Wang (ORCID: https://orcid.org/0000-0002-7039-5330)
- Yunwei Sun
- Ping He (ORCID: https://orcid.org/0000-0001-6490-8948)
- Yakun Zhang (ORCID: https://orcid.org/0000-0002-9636-8576)
- Weizhu Bao (ORCID: https://orcid.org/0000-0003-3418-9625)
- Difan Wang
- Yiwen Sun (ORCID: https://orcid.org/0000-0003-1014-4545)
- Ruidong Zhang
- Yusufu Rukeya
Institutions
- Shanghai Business School (CN)
- Shanghai Jiao Tong University (CN)
- Peking University (CN)
- Fudan University (CN)
- Renji Hospital (CN)
- Ruijin Hospital (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Shanghai Civil Aviation College (CN)
- Zhejiang University (CN)
- China National Petroleum Corporation (China) (CN)
Publication Details
- Journal
- Gut
- Published
- 2025-06-08
- DOI
- https://doi.org/10.1136/gutjnl-2024-334604
- Citations
- 4
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 5.86
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China