Marine natural product Methyl mycophenolate inhibits gastric cancer growth through regulating p53 and the downstream pathways
MMP displays anti-GC activity by inducing apoptosis and cell cycle arrest via the p53 pathway. Our findings suggest MMP's potential as a therapeutic agent for GC intervention.
Authors
- Lishi Xiao (ORCID: https://orcid.org/0000-0001-7917-0587)
- Xiaofang Liu (ORCID: https://orcid.org/0000-0002-8137-4201)
- Hongyan Yu (ORCID: https://orcid.org/0000-0002-5022-9861)
- Kaining Chen (ORCID: https://orcid.org/0000-0003-4878-0918)
- Ning Xu (ORCID: https://orcid.org/0000-0001-7909-7025)
- Honggang Ke
- Shi Chen (ORCID: https://orcid.org/0009-0003-9920-0247)
- Yufen Xu (ORCID: https://orcid.org/0000-0001-7062-4482)
- Dianying Feng
- Xiangqi Meng
- Jie Wang (ORCID: https://orcid.org/0000-0002-3879-0971)
Institutions
- Guangzhou University of Chinese Medicine (CN)
- Sun Yat-sen University (CN)
- Sixth Affiliated Hospital of Sun Yat-sen University (CN)
- Dalian Municipal Central Hospital (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Cancer Cell International
- Published
- 2025-06-08
- DOI
- https://doi.org/10.1186/s12935-025-03835-6
- Primary Topic
- Cancer-related Molecular Pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Basic and Applied Basic Research Foundation of Guangdong Province