ACUTE PHASE PROTEINS AS BIOMARKERS OF INFLAMMATION IN THERMAL INJURY

Determination of the concentration of acute phase proteins in blood plasma is a promising approach to assessing the degree of inflammation. The aim of the work was to study the levels of C-reactive protein (CRP), α1-acid glycoprotein (AGP), and ceruloplasmin (CP) in patients with thermal trauma. The concentration of CRP, AGP, and CP was measured in 27 patients with thermal injury (mean age 49.2 ± 5.3 years) on the 1st and 7th days of treatment. It was shown that at the early stage of burn injury, the concentration of CRP increased significantly (by 6.9 times), while the levels of AGP and CP were slightly elevated. A positive correlation was found between CRP concentration and burn area (r = 0.54, p < 0.05). On day 7, CRP and AGP remained elevated, while CP levels were normalized. The most informative indicator for assessing the dynamics of inflammation in burn trauma was CRP, while AGP may be useful for monitoring the prolonged inflammatory response. Thus, the analysis of acute phase proteins can be useful for monitoring inflammation and the effectiveness of treatment in patients with burns.