Histomorphological changes in the rat cerebral cortex following long-term caffeine consumption

Investigating the effects of coffee and caffeine on the frontal cortex is essential for understanding how these widely consumed dietary compounds influence higher cognitive functions such as decision-making, behavioral regulation, and impulse control. Caffeine, as a psychoactive stimulant, can impact neuroplasticity and neuronal health, potentially leading to structural alterations in brain regions associated with executive functions. These changes may manifest in histomorphological alterations such as neuronal loss, synaptic density changes, or modifications in glial cell activity, which in turn could influence behavioral outcomes and cognitive performance. Understanding these effects can inform recommendations on caffeine consumption and guide future research into therapeutic strategies targeting the frontal cortex.