Mutational landscape and DNA methylation-based classification of squamous cell carcinoma and urothelial carcinoma
We successfully established a DNA methylation-based classification for squamous cell carcinomas (lung, head and neck, esophagus, and cervix) and urothelial carcinomas with outstanding diagnostic performance for the first time. This classification has high potential for clinical translation to address the dilemma of identifying the origin of squamous cell carcinoma of unknown primary.
Authors
- Ran Wei (ORCID: https://orcid.org/0000-0002-5121-3650)
- Midie Xu
- Qianlan Yao (ORCID: https://orcid.org/0000-0003-0737-4147)
- Min Ren (ORCID: https://orcid.org/0000-0002-0019-5536)
- Chen Chen (ORCID: https://orcid.org/0000-0003-0900-5388)
- Qianming Bai (ORCID: https://orcid.org/0000-0003-0657-9845)
- Sheng Wu (ORCID: https://orcid.org/0000-0001-6630-3600)
- Qi Peng (ORCID: https://orcid.org/0000-0002-0763-3500)
- Liqing Jia (ORCID: https://orcid.org/0000-0003-1734-6043)
- Xiaoyan Zhou (ORCID: https://orcid.org/0000-0003-2805-0491)
- Qifeng Wang (ORCID: https://orcid.org/0000-0001-8544-9007)
- Xiaoli Zhu (ORCID: https://orcid.org/0000-0003-1723-4527)
- Qinghua Xu
Institutions
- Shanghai Medical College of Fudan University (CN)
- Fudan University (CN)
- Fudan University Shanghai Cancer Center (CN)
- ID Genomics (United States) (US)
Publication Details
- Journal
- Clinical Epigenetics
- Published
- 2025-06-08
- DOI
- https://doi.org/10.1186/s13148-025-01902-3
- Citations
- 1
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Shanghai Science and Technology Development Foundation
- Shanghai Municipal Health Commission
- Science and Technology Commission of Shanghai Municipality