Acute Respiratory Distress Syndrome and Spondylitis Secondary to Salmonella Bacteremia

<i>Salmonella enterica</i> subsp. <i>enterica</i> includes both typhoidal and non-typhoidal serovars. The former are more likely to cause systemic infections such as typhoid fever, while the latter typically result in localized gastroenteritis. The main symptoms of non-typhoidal <i>Salmonella</i> (NTS)infection are transient diarrhea, which typically resolves within approximately five days. However, in a few cases, it may worsen and cause multiorgan dysfunction. A 39-year-old healthy male developed an NTS infection, which likely manifested as enteritis, followed by <i>Salmonella</i> bacteremia, spondylitis, and acute respiratory failure. The patient required mechanical ventilatory support due to rapidly progressive respiratory failure; however, the respiratory condition improved within a short period following antibiotic therapy. Subsequently, prolonged antibiotic treatment was administered for spondylitis. While bone manifestations of NTS bacteremia are frequently reported, cases complicated by both acute respiratory distress syndrome (ARDS) and spondylitis are rare. The mechanism of pyogenic spondylitis development by <i>Salmonella</i> is thought to involve hematogenous infection associated with bacteremia. On the other hand, the pathogenesis of ARDS remains unclear. However, direct lung tissue damage caused by <i>Salmonella</i> and secondary lung injury resulting from systemic inflammatory response syndrome may play a role. This case highlights an unusual presentation in a relatively young and otherwise healthy adult.