Genetic overlap of severe psychiatric disorders with lung function and asthma suggests shared biological mechanisms
This study elucidates a complex shared genetic architecture for three severe psychiatric disorders with lung function and asthma and implicates overlapping immune and non-immune mechanisms. Our findings present novel evidence and putative mechanisms for a lung-brain axis underlying psychiatric disorders and lung diseases, which may inspire the development of novel treatments.
Authors
- Alexander Ploner (ORCID: https://orcid.org/0000-0002-5042-8326)
- Piotr Jahołkowski (ORCID: https://orcid.org/0000-0001-9408-3107)
- Alexey A. Shadrin (ORCID: https://orcid.org/0000-0002-7467-250X)
- Sarah E. Bergen (ORCID: https://orcid.org/0000-0002-5888-0034)
- Bronwyn K. Brew (ORCID: https://orcid.org/0000-0002-9885-8261)
- Zheng-An Lu
- Ole A. Andreassen
Institutions
- Oslo University Hospital (NO)
- Karolinska Institutet (SE)
- University of Newcastle Australia (AU)
Publication Details
- Journal
- Brain Behavior and Immunity
- Published
- 2025-06-08
- DOI
- https://doi.org/10.1016/j.bbi.2025.06.003
- Citations
- 1
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.16